Brown-Séquard syndrome, also called spinal cord hemisection, occurs when damage affects primarily one side of the spinal cord. This injury pattern was first described by French physician Charles-Édouard Brown-Séquard in 1850 and creates a characteristic set of neurological symptoms that distinguish it from other spinal cord injuries. The syndrome typically results from penetrating trauma, such as stab wounds or gunshot injuries, but can also occur from blunt force trauma in motor vehicle accidents, falls, or sports injuries.
The hallmark of Brown-Séquard syndrome is its asymmetric presentation. On the same side as the injury (ipsilateral), victims experience loss of motor function and proprioception (sense of body position). On the opposite side (contralateral), they lose pain and temperature sensation. This creates a confusing and challenging condition where one side of the body is paralyzed but can feel pain, while the other side has movement but cannot sense temperature or sharp pain.
Pure Brown-Séquard syndrome is relatively rare, accounting for approximately 2-4% of all traumatic spinal cord injuries. However, Brown-Séquard-plus syndrome, where the injury predominantly affects one side but has some bilateral involvement, is more common. The prognosis for Brown-Séquard syndrome is generally better than complete spinal cord injuries, with many patients regaining significant function through intensive rehabilitation. Studies show that approximately 75-90% of patients with Brown-Séquard syndrome regain the ability to walk, though they may continue to experience weakness, sensory deficits, and chronic pain.